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Daily intravenous injections in rats of five instances the normal human intravenous dose and intramuscular injections in dogs at four periods the standard human intramuscular dose demonstrated outstanding tolerance for as long as 6 weeks. Likewise, 2 times weekly anesthetic sessions of one, 3, or 6 several hours' duration in monkeys in excess of a 4- to six-7 days interval were properly tolerated.
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Ketamine hydrochloride injection is equipped as being the hydrochloride in concentrations similar to ketamine base.
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Respiration: Even though respiration is regularly stimulated, serious depression of respiration or apnea might arise pursuing fast intravenous administration of higher doses of ketamine hydrochloride.
The dosage and administration instructions as revealed in the instructions leaflet must be followed precisely.
It could selectively depress the thalamoneocortical system just before appreciably obtunding the greater historic cerebral facilities and pathways (reticular-activating and limbic systems).
The acute toxicity of ketamine hydrochloride has been researched in numerous species. In mature mice and rats, the intraperitoneal LD50 values are roughly 100 situations the standard human intravenous dose and roughly 20 occasions the average human intramuscular dose. A slightly larger acute toxicity noticed in neonatal rats wasn't adequately elevated to counsel an elevated hazard when used in pediatric individuals.
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